/PRNewswire/ -- Quest Diagnostics (NYSE: DGX), the world's leading provider of diagnostic information services, today released a new research report, The...
Physicians Foresee an Alzheimer's Disease Treatment Revolution Supported by Advanced Testing Tools, New Quest Diagnostics Report Finds - read this article along with other careers information, tips and advice on BioSpace
Transcript levels in plasma contribute substantial predictive value as potential Alzheimer's disease biomarkers in African Americans thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.
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Acadia Pharmaceuticals Announces August 4, 2022 Action Date for Resubmitted Supplemental New Drug Application for NUPLAZID® (pimavanserin) for the Treatment of Alzheimer’s Disease Psychosis - read this article along with other careers information, tips and advice on BioSpace
The Mediterranean diet (MedDiet) has been associated with cognitive performance. Yet, controlled trials have yielded contradictory results. To tackle this controversy, a comprehensive multimodal analysis of the association of the MedDiet with cognitive performance and brain structure in normative aging is still necessary. To address this issue, community-dwellers ≥50 years from a cohort study on normative aging (n=76) underwent a i) magnetic resonance imaging session with two acquisitions: structural and Diffusion-Weighted Imaging; ii) neuropsychological battery of tests focusing on memory and executive functioning and iii) dietary assessment through the Mediterranean Diet Assessment Screener (MEDAS) 18 months prior to the brain imaging and neuropsychological assessment. We found that high adherence to the MedDiet (MEDAS≥10) was associated with higher values of fractional anisotropy and lower diffusivity values in the brain white matter. Similarly, high adherence to the MedDiet was associated with higher structural connectivity between left hemisphere brain regions. Specifically, the rolandic operculum, amygdala, lingual, olfactory, middle occipital gyrus, inferior occipital gyrus and calcarine areas. No association was found between high adherence to the MedDiet and total brain volumes or hypointensities. Compared to participants with low adherence to the MedDiet, those with high adherence displayed statistically significant higher memory and executive functioning scores. These results suggest that high adherence to the MedDiet positively associates with brain health, specifically with cognitive performance and white matter bundles linking regions related to the processing and integration of taste, reward and decision-making. These findings support the view that the MedDiet should be part of recommendations to promote a healthy brain.
/PRNewswire/ -- While new year resolutions start with good intentions, the majority of them fail to take hold. In fact, research has found it takes an average...
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
The pathogenesis of Alzheimer's disease is complex, and early-onset Alzheimer's disease (EOAD) is mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), and amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with the PSEN2 mutation being the rarest. In this study, we reported a 56-year-old Chinese Han proband who presented with prominent progressive amnesia, aphasia, executive function impairment, and depression 5 years ago. The 3-year follow-up showed that the patient experienced progressive brain atrophy displayed on magnetic resonance imaging (MRI) and dramatic cognitive decline assessed by neuropsychological evaluation. This patient was clinically diagnosed as EOAD based on established criteria. A heterozygous variant (NM_000447.2: c.1106T>C) of PSEN2 was identified for the first time in this patient and her two daughters. This mutation causing a novel missense mutation (p.Phe369Ser) in transmembrane domain 7 encoded by exon 11 had not been reported previously in 1000Genomes, ExAC, or ClinVar databases. This mutation was predicted by four