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Scientists Find a Natural Protein That Stops Allergies And Autoimmune Conditions
11 MARCH 2021
For the millions of us plagued by hypersensitive, overactive, or downright abusive immune systems, it can feel like you're constantly fighting your own physical self.
From incessant allergies to life-threatening anaphylaxis and debilitating autoimmune disease, the system that's supposed to be protecting us can be problematic when it goes wrong. Now, we might be closer to fixing these issues in an entirely new way.
Using transgenic mice and cultures of cells taken from human tonsils, researchers have now found evidence of how our bodies might defend against the mistakes that result in conditions such as asthma, food allergies, and lupus. They found a protein called neuritin, produced by immune cells. It acts a bit like an inbuilt, boss-level antihistamine.
AustraliaAustralianPaula-gonzalez-figueroaAustralian-national-universityCellsNeuritinImmuneAmp-quotAllergiesAuto-immuneMiceAntibodiesCanberra researchers at the Australian National University find a protein that could stop allergic reactions and anaphylaxis
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MarMarch 2021 at 3:52am
Dr Paula Gonzalez Figueroa spent years working off a guess that neuritin had a regulatory function in stopping allergies and autoimmunity.
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Thousands of people live with allergies and autoimmune diseases, and that number is only rising, for reasons that are not entirely clear to medical researchers.
Key points:
It has the potential to tackle numerous conditions, including autoimmune diseases and asthma
The researchers hope to develop better treatments than EpiPens or ventolin
AustraliaCanberraAustralian-capital-territoryAustralianPaula-gonzalez-figueroaMichaela-lucasAustralian-national-universityAnaphylaxisAllergyAuto-immuneDiseaseAnusocaltech.com
Encinitas-based
Ventyx Biosciences, a developer of immune modulators to treat inflammatory diseases and autoimmune disorders, said this morning that it has raised $114M in an equity funding round. The funding was led by venBio Partners, and also included Third Point, RTW Investments, LP, Janus Henderson Investors, Wellington Management, OrbiMed, Surve
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WellingtonNew-zealand-generalNew-zealandVentyx-biosciencesBiosciences-takesBio-partnersThird-pointJanus-henderson-investorsWellington-managementVentyxBiosciencesCOVID can make the body attack itself. Medical imaging shows the results.
With the help of medical imaging, a new study is illustrating for the first time some of the rare consequences of COVID-19: how the disease can trick the body into attacking its own muscles, joints and nerves.
and last updated 2021-03-01 11:06:22-05
SAN DIEGO (KGTV) -- With the help of medical imaging, a new study is illustrating for the first time some of the rare consequences of COVID-19: how the disease can trick the body into attacking its own muscles, joints and nerves.
The study, published in the journal
Swati-deshmukhNorthwestern-universitySkeletal-radiologyCovid-toesCovid-19MriAchesAuto-immuneAutoimmune-myositisImmune-responseJoint-painMuscle-pain(1)
BEDMINSTER, N.J., Feb. 25, 2021 /PRNewswire/ -- Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced a collaboration with Boston Children's Hospital (https://wistar.org/) to evaluate peptidyl arginine deiminase 4 (PAD4) inhibitors under development by Jubilant Therapeutics to explore the modulation of neutrophil extracellular traps (NETosis) in preclinical models of neutrophil regulation and rheumatoid arthritis (RA).
PAD4 is an enzyme that converts arginine to citrulline in histones and is highly expressed in neutrophils. Histone citrullination has been implicated in the formation of NETs which is believed to contribute to pro-inflammation and disease progression in many autoimmune disorders including RA, fibrosis, lupus and ARDS.
BostonMassachusettsUnited-statesKostenloser-wertpapierhandelSyed-kazmiDenisa-wagnerLinkedinHarvard-medical-schoolJubilant-therapeutics-incJubilant-life-sciencesNational-academy-of-medicineNational-academy-of-sciences Conditions
Feb 2, 2021 03:41 PM By Sabrina Emms A new study links autoimmune disease in an expectant mother with the increased chance of her child having ADHD. Photo courtesy of Shutterstock
Parents pass all kinds of things down to their kids - red hair, bad eyesight, maybe even a taste for spicy food. Sometimes, the health conditions of a parent can make an impact on the child. This is the case with autoimmune disorders in mothers, and ADHD in their children. New research, published in JAMA Pediatrics, explored the connection.
Typically, when we think of parents passing things down, it is because of genetics, like blood type, where the child's blood type is a combination of the parents'. That’s not what researchers think is going on with the autoimmunity/ADHD connection. Genetics does play a role, but new research points to the time a fetus spends inside its mother as a contributing factor.
AustraliaTimothy-nielsenMedical-dailyNew-south-walesTranslational-psychiatryAuto-immuneAutoimmunityAdhdAttention-deficit-hyperactivity-disorderPregnancyPregnant