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Targeting tough bacteria: Durham biotech startup advances synthetic antibiotic technology

Editor’s note: Deep Dive – a feature looking in depth at timely issues from tech to jobs – is a regular feature on Wednesdays in TechWire. +++ RESEARCH TRIANGLE PARK - It’s often said that success doesn’t happen overnight. Consider Durham-based anti-infectives startup ValanBio Therapeutics. The journey that led to the development of its new synthetic antibiotic

Synthetic Antibiotic Strategy against Gram-Negative Bacteria

Duke researchers develop potent antibiotic against drug-resistant superbugs

A scientific journey decades in the making at Duke University has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections (UTIs).

A new synthetic antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli

Synthetic antibiotic could be effective again

A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all.

Synthetic antibiotic could be effective against drug-resistant superbugs

Synthetic antibiotic could be effective again

A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all.

Synthetic Antibiotic Could Be Effective Against Drug-Resistant Superbugs

Synthetic antibiotic could be effective against drug-resistant superbugs: Decades of work by a series of Duke investigators yields new drug, patents and a startup company

LK-99: Could this superconductor 'discovery' really change the world?

LK-99's discovery, detailed in two papers from South Korea in late July, sent social media into a frenzy - but the world's scientists are far from convinced we're on the precipice of a revolution just yet.