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Some studies show that low serum vitamin D levels are associated with white matter hyperintensity (WMH）, while other studies report no association. This meta-analysis aimed to investigate the presence of an association between serum 25-hydroxy vitamin D [25(OH)D] levels andWMH. PubMed, Embase, the Cochrane Library, CNKI, WANFANG, and VIP were searched for available papers published up to December 2020. The outcomes were the odds ratios (ORs) with 95% confidence intervals (CIs) for the association between different vitamin D statuses andWMH. All meta-analyses were performed using a random-effects model. Five studies (4393 patients) were included. Compared with sufficient 25(OH)D levels, 25(OH)D deficiency was not associated with WMH(OR=1.67, 95%CI: 0.92-3.04; I2=70.2%, Pheterogeneity=0.009), nor was 25(OH)D insufficiency (OR=1.21, 95%CI: 0.89-1.65; I2=48.1%, Pheterogeneity=0.103) (Figure 3). A decrease of 25 nmol/L in 25(OH)D levels was associated with WMH(OR=1.83, 95%CI: 1.34-2.49; I