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Botched Enrollment Seen as Ruining Big Xarelto Trial

email article The failure of low-dose rivaroxaban (Xarelto) in the international COMMANDER-HF trial was traced back to aberrant patient recruiting practices and poor medication adherence in the largest enrolling region, one group found. Study participants in Eastern Europe were unusually young and less likely to have coronary interventions and cardiac devices at enrollment. They also tended to have better renal function, lower plasma concentrations of BNP or NT-proBNP, and higher left ventricular ejection fraction, according to researchers led by João Pedro Ferreira, MD, PhD, of Centre Hospitalier Régional Universitaire de Nancy, Hopitaux de Brabois, France. Moreover, the Eastern Europe subgroup had a uniquely low incidence of the primary endpoint (combined MI, stroke, or all-cause death) over the course of the trial:

Anexo C: técnicos, preocupados por "espíritu entreguista" - Nacionales

Itaipú y Yacyretá sincronizan sus sistemas por primera vez

Negociadores que revisarán Anexo C generan muchos cuestionamientos

Portugal gets ready for World Youth Day despite delays

Lisbon is set to host the world's largest gathering of young Catholics in 2023

Manifestación contra "entreguistas" moviliza a un pelotón en torno a Mburuvicha Róga - Nacionales

Abdo ya no lee sobre corrupción en su gestión y se escuda en la Biblia

WYD organizers release official theme song for Lisbon 2023 gathering

WYD organizers release official theme song for Lisbon 2023 gathering Jan 28, 2021 catholic news service A young man participates in the recording of the official theme song for the Lisbon 2023 World Youth Day in Torres Vedras, Portugal, Aug. 5, 2020. The official song is titled "Ha Pressa no Ar" (There Is Urgency in the Air). World Youth Day has been postponed until August 2023 because of the coronavirus pandemic. (Credit: CNS photo/Filipe Amorim, World Youth Day Lisbon.) World Youth Day organizers released the winning theme song for the international gathering in Lisbon, Portugal, in 2023. ROME — World Youth Day organizers released the winning theme song for the international gathering in Lisbon, Portugal, in 2023.

Godoy dispara contra Abdo: "Ya no cabe ninguna duda de que él es el principal corrupto"

Peña dice que fue un error cambiar a Federico González: "Tiene condiciones para ser canciller y todo en contra para director de Itaipú"