Summary
New cryo-electron microscopy images suggest archaeal microbes pack their chromatin into tight coils that can spring open, forming unexpected contortions.
Archaeal DNA forms coils that can flop apart in solution, new cryo-electron microscopy experiments reveal. Credit: S. Bowerman et al./
eLife 2021
In some single-celled organisms, DNA coils like a spring and opens like a book.
eLife. “Very much to our surprise, we found that these structures can undergo all sorts of gymnastics,” says Luger, a biochemist at the University of Colorado Boulder.
Like DNA in the nucleus of human cells, archaeal DNA coils around proteins like string wrapped around a yo-yo. But there’s another twist, the team found. Those coils of DNA can also spread 90 degrees apart – a phenomenon scientists hadn’t seen before. Such bends in the springlike structures could potentially let archaeal proteins sidle up to the DNA and switch genes on and off, Luger suggests. (Scientists don’t currentl
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Fred Hutch announces 2021 Harold M. Weintraub Graduate Student Award recipients
Thirteen graduate students selected for prestigious honor in biological sciences Photos of award recipients Jeremy Mseitif
SEATTLE March 1, 2021 Fred Hutchinson Cancer Research Center today announced the recipients of the 2021 Harold M. Weintraub Graduate Student Award, which recognizes outstanding achievement in graduate studies in the biological sciences. The 13 award recipients were selected for the quality, originality and significance of their work, representing a diverse range of research topics.
Nominations for this prestigious annual award are solicited internationally. This year’s awardees come from across the U.S. from the University of California, Los Angeles to the University of Texas Southwestern Medical Center to Harvard University and three international recipients from the University of Basel, Switzerland, the University of St. Andrews, UK, and the