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Chronic GVHD Therapies Offer Hope for Treating Refractory Disease
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Dr Karen Cerosaletti, Ph D , 82: Medical researcher gets a chance to give back
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White House announces $1 6B effort to boost coronavirus testing, sequencing
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New coronavirus variants are emerging across the globe: Everything we know CNET 2/17/2021 © Bloom Lab (https://jbloomlab.github.io/SARS-CoV-2-RBD DMS/)
Maps like these, produced by the Bloom lab at the Fred Hutchinson Cancer Research Center, guide research on mutations. At significant sites in the RBD, the team analyzes how mutants change the binding affinity. Blue is increased affinity, red is decreased. The N501Y mutant is a deep blue, showing how this mutant has increased binding affinity to ACE2.
The coronavirus SARS-CoV-2 has constantly evolved since it was first detected in humans over a year ago. Viruses replicate exceedingly fast, and each time they do, there s a small chance they mutate. This is par for the course, if you re a virus .
Drew Weissman realized a year ago that even if the COVID-19 vaccines then in progress were eventually approved, it might not be enough. The world might need a next-generation vaccine to rid itself of this pandemic.
Recent outbreaks of more resilient variants suggest he could be right. And yet, when Weissman – discoverer of the mRNA science behind two of the current vaccines – and a team of fellow scientists took a proposal for a more versatile COVID-19 vaccine to the National Institutes of Health for funding last May, they left empty-handed.
The group had proposed research on vaccines to protect against any variant of the virus, known as a universal or pan vaccine.