Washington, Jan 7: Nearly 4,400 adverse events were reported after people received the Pfizer-BioNTech COVID-19 vaccine in the US, with 21 cases determined to be anaphylaxis, according to a report by the Centers for Disease Control and Prevention (CDC).
Some researchers suggest that a single-dose regimen of available vaccines might offer a lower, but still substantial level of protection against Covid-19.
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First case of new COVID-19 variant now confirmed in Texas
First case of new COVID-19 variant now confirmed in Texas By ABC13 Staff The COVID19 variant B.1.1.7 has struck an area man.
Andriy Onufriyenko/Getty Images Harris County Public Health has confirmed the first case of the COVID19 variant B.1.1.7, the same variant discovered in the UK. This the first known case in the state of Texas. The patient has been identified as a man between ages 30 and 40 in southwest Harris County. His condition is described as stable, and the man is quarantining in isolation. Authorities say he has no travel history and are reaching out to anyone the man has come into contact with.
PI3K/AKT/mTOR Inhibitors for Prostate Cancer – Finally Hints of a Breakthrough
Published 05 January 2021
Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has been strongly linked with prostate cancer progression and metastatic potential.
1 Loss of the inhibitory phosphatase, PTEN, leading to hyperactivation of PI3K/AKT/mTOR oncogenic signaling, occurs in 40-50% of metastatic castration-resistant prostate cancer.
1,2 Not surprising is the fact that PTEN loss in patients with metastatic castration-resistant prostate cancer is associated with a worse prognosis and less benefit from androgen receptor (AR) blockade.
3 Likewise, PTEN loss and subsequent Akt activation confer radiation