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Here are the latest coronavirus updates from the U.S. and elsewhere:
California Governor Says COVID-19 Variant Was Detected in Southern California
California Gov. Gavin Newsom on Wednesday announced in a joint news conference with Dr. Anthony Fauci that the COVID-19 variant found in the U.K. and in Colorado has been detected in Southern California. An hour or so ago we were informed that this new variant, this new strain that we’ve identified from the United Kingdom…. and in Colorado yesterday has been identified here in the state of California, in Southern California, Newsom said.
The announcement came after Newsom recommended in-person learning continue in California schools in the coming year.
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“There is a lot we don’t know about this new COVID-19 variant, but scientists in the United Kingdom are warning the world that it is significantly more contagious, Colorado Gov. Jared Polis said. The health and safety of Coloradans is our top priority, and we will closely monitor this case, as well as all COVID-19 indicators, very closely.
The discovery of the mutated version overseas led the U.S. Centers for Disease Control and Prevention to issue rules on Christmas Day requiring travelers arriving from Britain to show proof of a negative COVID-19 test.
The variant is probably still rare in the U.S., but the lack of travel history in the first case means it is spreading, perhaps seeded by visitors from Britain in November or December, said scientist Trevor Bedford, who studies the spread of COVID-19 at the Fred Hutchinson Cancer Research Center in Seattle.
A form of inflammatory cell death called panoptosis triggers the storm of cytokines, or inflammatory proteins, that causes critical illness in COVID-19, researchers say. During inflammatory cell death, cells spew out their contents instead of neatly packaging them away as happens during routine cell death, Thirumala-Devi Kanneganti of St. Jude Children s Research Hospital told Reuters. Neighboring cells see the cytokines released and the other unexpected debris as a sign of danger, and they can respond by secreting more cytokines, allowing the cytokine storm to build.
Her team identified a synergy between two cytokines, TNF-alpha and IFN-gamma, as the cause of panoptosis in COVID-19. Mice given TNF-alpha and IFN-gamma developed the symptoms and organ damage of COVID-19 and died rapidly, Kanneganti said.