Have you experienced fever or swelling in the morning with stiff or sore joints? The cause of rheumatoid arthritis – a chronic inflammatory joint disease that can occur in various joints such as hands, wrists, feet and ankles – is still unknown. As s
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IMAGE: The E. coli chromosome was split into three 1-Mb chromosomes, and the chromosome was used for genome implantation. view more
Credit: Rikkyo University
Escherichia coli (
E. coli) genome, consisting of 4.6 million base pairs of a single circular DNA, is too large to manipulate following the extraction and transfer to other bacteria.
In the present study, a group of Rikkyo University researchers led by Assistant Professor Takahito Mukai and Professor Masayuki Su etsugu has succeeded in splitting the E.coli genome into tripartite-genome of 1 million base pairs per genome (split-genome) using the smallest
E. coli genome strain established so far. In addition, they successfully extracted the split-genome from bacteria and installed it in other
Credit: Weizhi Ji, Kunming University of Science and Technology
Investigators in China and the United States have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications for developing new models of human biology and disease. The work appears April 15 in the journal
Cell. As we are unable to conduct certain types of experiments in humans, it is essential that we have better models to more accurately study and understand human biology and disease, says senior author Juan Carlos Izpisua Belmonte, a professor in the Gene Expression Laboratory at the Salk Institute for Biological Sciences. An important goal of experimental biology is the development of model systems that allow for the study of human diseases under in vivo conditions.
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HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target
HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target. The research was led by Dr Ruby Hoo Lai-chong (second from left), Assistant Professor, Department of Pharmacology and Pharmacy, HKUMed and Co-investigator of State Key Laboratory of Pharmaceutical Biotechnology, HKU. Dr Wu Xiaoping (second from right), post-doctoral fellow, Department of Pharmacology and Pharmacy, HKUMed is the first author. Other research team members include: Ms Zong Jiuyu (left) and Ms Zhang Zixuan (right), postgraduate student, Department of Pharmacology and Pharmacy, HKUMed.