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Want to Be Robust at 40-Plus? Meeting Minimum Exercise Guidelines Won t Cut It

Want to Be Robust at 40-Plus? Meeting Minimum Exercise Guidelines Won t Cut It
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DOACs Safe, Effective in Subset of Valvular AF Patients

March 31, 2021 Helping to fill an evidence gap, a retrospective review of a large database of US commercial health claims indicates that in patients with valvular atrial fibrillation (AF), direct oral anticoagulants (DOACs) are associated with lower risks of stroke, systemic embolism, and major bleeding compared with warfarin. The findings shed light on a topic that has proved confusing for clinicians due to the different definitions of “valvular heart disease” used across clinical trials and guidelines. Patients with both AF and valve disease were excluded from the randomized trials that led to the approval of apixaban (Eliquis; Bristol-Myers Squibb), edoxaban (Savaysa; Daiichi-Sankyo), rivaroxaban (Xarelto; Bayer/Janssen), and dabigatran (Pradaxa; Boehringer Ingelheim) in the United States, so their safety and efficacy in this setting remains unclear.

Roughly 80% of ESC Guideline Writers Have Financial COIs

April 01, 2021 The vast majority of experts who write and review some of the major clinical guidelines issued by the European Society of Cardiology (ESC), including those for ischemic heart disease, valvular heart disease, atrial fibrillation, and heart failure, have financial conflicts of interest, according to a new analysis. These entanglements, whether or not they affect the final product, could raise doubts among clinicians and patients that undermine the guidelines’ message, sources told TCTMD. Breaking down the type of conflicts seen across the different ESC documents, receipt of a direct personal payment, either for industry-funded talks, consulting work, or payments for serving on an advisory board, a committee, or as a clinical investigator, largely outpaced payments made directly to the hospital or money for research funding.

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