Lung cancer patients should be screened for MET oncogene amplification, research suggests
Research by investigators at Mayo Clinic Cancer Center suggests that physicians should screen patients with lung cancer for MET amplification/overexpression before determining a treatment strategy. Their findings are published
Cancer Discovery, a journal of the American Association for Cancer Research. In our research we found several lung cancer cases that were not responsive to standard chemotherapy, says Zhenkun Lou, Ph.D., a cancer researcher at Mayo Clinic. Because these lung cancers were positive for PD-L1, a protein that allows some cells to escape attack by the immune system, we then tried treating these patients with anti-PD1 immunotherapy to relieve PD-L1 mediated immune suppression, however this treatment also failed.
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