While only 15-20% of human lung cancer tumors currently respond to immune checkpoint blockade, research team’s new approach was to induce the regression of about 70% of the tumors.”
A two-arm molecule can effectively deplete cancer-protecting cells inside tumors, allowing the immune system to fight off tumors without becoming overactive. The finding, published online in Science Translational Medicine, could lead to new types of cancer immunotherapies.
Lung cancer is the leading cause of cancer-related death. Current treatments employ immunotherapy, often in combination with chemotherapy, but benefits to patients remain slight.
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