Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. The team found that the compound, named C28, not only prevents or reverses the negative physiological effects on the action potential, but does
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IMAGE: Xiaoqin Zou, professor of physics, biochemistry, and a member of the Dalton Cardiovascular Research Center and Institute for Data Science and Informatics at the University of Missouri view more
Credit: University of Missouri
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when take
DiAntonio, Milbrandt honored for innovation, entrepreneurship
May 7, 2021 SHARE
Jean Allman and Lilianna Solnica-Krezel will receive Washington University in St. Louis’ 2021 faculty achievement awards, Chancellor Andrew D. Martin announced.
Allman, PhD, the J.H. Hexter Professor in the Humanities and professor of African and African American studies, as well as director of the Center for the Humanities, all in Arts & Sciences, will receive the Arthur Holly Compton Faculty Achievement Award. Solnica-Krezel, PhD, the Alan A. and Edith L. Wolff Distinguished Professor and head of the Department of Developmental Biology at the School of Medicine, will receive the Carl and Gerty Cori Faculty Achievement Award.
UMMS establishes gene therapy collaborative research agreement with Pfizer
Researchers will evaluate productivity and quality determinants of recombinant adeno-associated virus production
UMass Medical School Communications April 08, 2021
UMass Medical School has entered into a three-year, collaborative research agreement with Pfizer to evaluate determinants that influence the manufacturing quality and yield of viral vectors used in gene therapy. The research is being jointly conducted by Pfizer and UMMS, with the research at UMMS being performed under the direction of Guangping Gao, PhD, the Penelope Booth Rockwell Professor in Biomedical Research, professor of microbiology & physiological systems, director of the Horae Gene Therapy Center and co-director of the Li Weibo Institute for Rare Diseases Research, and Dan Wang, PhD, assistant professor of RNA therapeutics.
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