US$ 442.5 million in 2020 and is expected to exhibit a CAGR of 3.9%
during the forecast period (2020-2027).
Key Trends and Analysis:
The
MENA biologics & biosimilars market is expected to witness significant growth, owing to increasing prevalence of Age-related Macular Degeneration (AMD). For instance, according to the study in Saudi Medical Journal 2015, in Saudi Arabia, AMD represents 3.3% of the major causes of blindness in individuals older than 50 years.
The increasing approval and new drug launches are expected to propel the market growth. For instance, in 2017, Swedish Orphan Biovitrum AB (Sobi) received Saudi Food & Drug Authority (SFDA) approval for Elocta (efmoroctocog alfa), a recombinant human factor VIII Fc-fusion protein with an extended half-life, for the treatment of hemophilia A.
Actimed Therapeutics Appoints Frank Misselwitz MD, PhD as Chief Medical Officer
Joins Actimed following highly successful 20-year career at Bayer
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LONDON, Feb. 2, 2021 /PRNewswire/ Actimed Therapeutics, the clinical stage company focused on bringing innovation to the treatment of muscle wasting disorders, with a focus on cachexia, today announces the appointment of Frank Misselwitz MD, PhD, as Chief Medical Officer.
Dr Misselwitz joins the Company in his new role from Bayer AG where until recently he was Corporate Vice President and Therapeutic Area Head in clinical development. With a background in academia and industry, he has over 30 years of extensive pharmaceutical industry experience. Dr Misselwitz is currently a non-executive director and member of the Board of Actimed.
More than a third of patients with pretreated non-small cell lung cancer (NSCLC) and a
KRAS G12C mutation responded to the investigational agent sotorasib, findings from a phase II study showed.
Among 126 NSCLC patients with locally advanced or metastatic disease, most of whom had their disease progress following treatment with both chemotherapy and a checkpoint inhibitor, 37.1% had a confirmed response to the KRAS G12C inhibitor (95% CI 28.6-46.2), including complete responses in 2.4%, reported Bob T. Li, MD, PhD, of Memorial Sloan Kettering Cancer Center in New York City.
An additional 43.5% achieved stable disease as their best response, for a disease control rate of 81% (95% CI 72.6-87.2%), according to findings presented at the virtual World Conference on Lung Cancer (WCLC).
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Patients with previously treated advanced non-small cell lung cancer had similar overall survival (OS) with docetaxel and nab-paclitaxel (Abraxane), but the latter improved progression-free survival (PFS) and was better tolerated, a randomized trial showed.
Median OS improved from 13.6 months with docetaxel to 16.2 months with nab-paclitaxel. The difference did not achieve statistical significance but met the trial s primary objective of noninferiority. The protein-bound paclitaxel formulation offered a slight PFS advantage and led to a significantly higher objective response rate (ORR).
Grade 3/4 hematologic toxicity and febrile neutropenia occurred substantially more often with docetaxel, whereas nab-paclitaxel caused more peripheral sensory neuropathy, reported Atsushi Nakamura, MD, of Sendai Kousei Hospital in Miyagi, Japan, during the virtual World Conference on Lung Cancer.
Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer
A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.
Lung cancer researchers and clinicians have sought methods to improve chemotherapy s modest 5% overall survival rate for patients with NSCLC. Dr. Silvia Novello, professor of medical oncology at the University of Torino at San Luigi Gonzaga Hospital, Orbassano, Italy, and a large group of European researchers evaluated the predictive utility of the mRNA expression levels of molecular markers, mRNA expression levels of molecular markers, excision repair cross-complementing group ERCC1 and th