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A personalized anti-cancer vaccine that works in mice

 E-Mail Marie-Claude Bourgeois-Daigneault and her team at the CRCHUM are using mice to show how a combination of peptides and oncolytic viruses, used as an adjuvant, can provide effective immunization against cancer. In her laboratoryat the University of Montreal Hospital Research Centre (CRCHUM), Marie-Claude Bourgeois-Daigneault and a team of scientists usually modify viruses to make them specific to the cells of a tumour. Once in the patient s body, these viruses, called oncolytic viruses, infect and specifically destroy the cancer cells without touching healthy cells. These viruses can even stimulate the immune system so that it is better armed to recognize and kill malignant cells. This is immunotherapy.

Avocado discovery may point to leukemia treatment

Avocado discovery may point to leukemia treatment A compound in avocados may ultimately offer a route to better leukemia treatment, says a new University of Guelph study. The compound targets an enzyme that scientists have identified for the first time as being critical to cancer cell growth, said Dr. Paul Spagnuolo, Department of Food Science. Published recently in the journal Blood, the study focused on acute myeloid leukemia (AML), which is the most devastating form of leukemia. Most cases occur in people over age 65, and fewer than 10 per cent of patients survive five years after diagnosis. Leukemia cells have higher amounts of an enzyme called VLCAD involved in their metabolism, said Spagnuolo.

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