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Continuous Processes: Keeping Them Safe from Viruses

Continuous Processes: Keeping Them Safe from Viruses Sponsored Content by Pall CorporationMay 21 2021 Virus safety is a crucial part of biopharmaceutical manufacturing. There are intrinsic risks related to virus safety in the handling of animal cell culture. Chinese Hamster Ovary (CHO) cell lines are the most frequently found production platform for expressing glycosylated proteins and monoclonal antibodies. Image credit: Pall Corporation Due to their rodent origins, CHO cell lines can harbor endogenous retroviruses or retrovirus-like particles. Additional virus safety risks arise from the potentiality that the cell culture could be compromised by adventitious viruses. Consequently, the regulatory expectation for manufacturing platforms is to demonstrate the capacity to eliminate or inactivate a broad range of viruses to limit the impact of viruses on the safety of patients.

Using Stirred Tank Bioreactors for Upstream Flexibility

Using Stirred Tank Bioreactors for Upstream Flexibility Sponsored Content by Pall CorporationMay 21 2021 When utilized in respect of upstream biopharmaceutical manufacturing, flexibility denotes the simplicity of setting up, scaling up, and switching between batches and various processes. Image credit: Pall Corporation Outstanding and enhanced flexibility is one of many key advantages of single-use systems (SUSs) and a primary reason why the adoption rate of SUS is so high. The more flexible single-use systems mean that processes can be developed and delivered a lot faster than stainless steel-based facilities. This element is of vital importance in the global context of the race for a vaccine against COVID-19, which necessitates an industry-wide effort to hasten the development of vaccine candidates and to fundamentally support the accelerated manufacture of the billions of doses required for clinical trials and vaccination programs around the world.

Help is at hand for those buying their first home or thinking of self-building

Help is at hand for those buying their first home or thinking of self-building
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