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Frequent and accurate RT-PCR–based testing is essential for preventing and managing SARS-CoV-2 infection; however, active infection surveillance is still often limited by time or resources. Cleary et al. demonstrate that considering population-level viral prevalence and individual viral loads allows for efficiency gains upon pooled testing with minimal loss of sensitivity, both theoretically and as validated in vitro using human swab and sputum samples. Barak et al. show that pooled testing of 133,816 hospital-collected patient nasopharyngeal samples eliminated three quarters of testing reactions with only a minor reduction in sensitivity, demonstrating the efficacy of the approach in the field. Both studies suggest that considered pooling of individual samples before testing could reliably increase SARS-CoV-2 testing throughput. Virological testing is central to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) containment, but many settings face severe limitations on te

United statesMonte carloBroad institute clinical laboratory improvement amendmentsBroad institute of massachusetts technologyBroad institute office of researchEmergency use authorizationSupplementary materialsBroad institute officeSponsored programsBroad instituteMassachusetts instituteஒன்றுபட்டது மாநிலங்களில்மான்டே கார்லோபரந்த நிறுவனம் ஆஃப் மாசசூசெட்ஸ் தொழில்நுட்பம்அவசரம் பயன்பாடு அங்கீகாரம்துணை பொருட்கள்