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Nanotherapy shows potential for treating severe Crohn s disease Scientists from the Stanley Manne Children s Research Institute at Ann & Robert H. Lurie Children s Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn s disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers. It might also prevent the need for surgery in the future. Findings were published in the journal Advanced Therapeutics. Crohn s disease is an inflammatory bowel disease characterized by chronic inflammation of the digestive tract, most often in the small intestine. It can lead to intestinal obstruction and perforation, bleeding, abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition leading to growth abnormalities in children.

Varun sharmaEmily hendersonMccormick school of engineeringManne research institute at lurie childrenResearch associate professor of urologySurgical researchStanley manne childrenResearch instituteSenior authorManne research instituteLurie childrenResearch associate professorBiomedical engineeringNorthwestern university feinberg schoolMccormick schoolCrohn 39s disease