Multi-institutional team combined expertise to make discovery
May 17, 2021 SHARE
Dozens of commonly used drugs, including antibiotics, anti-nausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart’s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination.
Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. The team found that the compound, named C28, not only prevents or reverses the negative physiological effects on the action potential, but does
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IMAGE: Xiaoqin Zou, professor of physics, biochemistry, and a member of the Dalton Cardiovascular Research Center and Institute for Data Science and Informatics at the University of Missouri view more
Credit: University of Missouri
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when take
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(Illustration: Monica Duwel/Washington University)
March 11, 2021 SHARE
A city the density of Atlanta or Milwaukee, over a half-million strong, tragically has been wiped from the face of America’s future. Thousands of businesses disappeared, never to return. Millions remained out of work or hardly strayed out of their home, for work or play.
A dose or two of hope, however, arrived near the end of the pandemic’s first year in the form of not one, not two, but three record-breaking vaccines for the dreaded, unseen virus that causes COVID-19.
So where do we go from here, in the second year in these times of coronavirus?