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Researchers at Baylor College of Medicine and collaborators at other institutions have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner. Researchers found that female mice with glioma that lacked the gene survived less than males. This led them to investigate human glioma cells, where they found that low POT1 expression correlated with reduced survival in females.
Published in the journal
Cancer Research, the study also shows that, compared to males , female tumors had reduced expression of immune signatures and increased expression of cell replication markers, suggesting that the immune response and tumor cell proliferation seemed to be involved in favoring tumor growth.
POT1 gene mutation predisposes to glioma and affects survival in a sex-specific manner
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Only 2 300 vaccinated against Covid so far - Health
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JEMIMA BEUKES
WINDHOEK
The Anti-Corruption Commission (ACC) is still occupied with an investigation into alleged corrupt practices by health ministry senior pharmacist Fabiola Vahekeni - despite the ministry having exonerated her on the same matter.
ACC spokesperson Josephina Nghituwamata confirmed that the investigation had been concluded and said the matter was submitted to Prosecutor-General (PG) Martha Imalwa with its relevant information.
“Thereafter, the docket was referred back to the ACC with instructions. The commission up to this point conformed to the instructions; subsequently, it will soon be sent back to the PG’s office,” Nghituwamata said.
Meanwhile, the health ministry has concluded an internal investigation and cleared Vahekeni of any wrongdoing. This was prompted by a previous investigation by the finance ministry, which urged its health counterpart to charge Vahekeni for misconduct.