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New inhibitor makes drug-resistant tumor cells respond again to chemotherapy

New inhibitor makes drug-resistant tumor cells respond again to chemotherapy A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumor cells respond again to chemotherapy. The new substance blocks a protein in the cancer cells that normally transports the cancer drugs back out of the cells. The results were published in the scientific journal Molecules. In addition to radiation therapy, cytotoxic agents, also known as chemotherapy, are frequently used to treat cancer. They prevent cells from dividing and thus cancer cells are unable to multiply unchecked.

Researchers develop a new approach to detect pancreatic cancer

Credit: ACS Pharmacol. Transl. Sci. Nov./Dec. 2020 (3, 6), © 2020 American Chemical Society A protein found commonly in human blood might help with the detection of hard-to-diagnose pancreatic tumours. Researchers at Martin Luther University Halle-Wittenberg (MLU), the Alfried Krupp Hospital in Essen and the University of Witten/Herdecke have developed approach using the protein s structure and its function as a proxy for this. In a first study in ACS Pharmacology & Translational Science, the team shows how its method can also be used to differentiate between benign and malignant tumours. Pancreatic cancer is particularly insidious: It remains asymptomatic for a long time, which leads to very late diagnoses and therefore a low chance of treating it successfully, says Dr Marcos Gelos from the Alfried Krupp Hospital and Witten/Herdecke University who headed up the new study together with Professor Dariush Hinderberger, a chemist at MLU. Nine out of ten patients succumb to the di

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