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© V. Namasivayam/Pharmazeutisches Institut/Uni Bonn A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as therapeutic drugs. The results have now been published in the journal In order for the SARS-CoV-2 coronavirus to replicate, it relies on the main protease as a key enzyme. The virus first has its genome translated from RNA into a large protein strand. The viral main protease then cuts this protein chain into smaller pieces, from which the new virus particles are formed. The main protease is an extremely promising starting point for coronavirus drug research, says professor Dr. Christa E. Müller of the Pharmaceutical Institute at the Uni

Nordrhein westfalenVigneshwaran namasivayamMaria zyulinaPhuong vuV namasivayam pharmazeutisches institutJulian breidenbachMiriam diettKatharina sylvesterGhazl al hamwiCarina lemkeAngewandte chemieUniversity of bonnInstitute of the university bonnTransdisciplinary research area lifeResearchers findPharmaceutical institute