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Glycated hemoglobin (HbA1c) could have prognostic value for people without diabetes and no history of cardiovascular disease (CVD), according to an observational study of nearly 4,000 middle-age individuals.
In the PESA study, HbA1c showed a graded, positive association with the prevalence and multi-territorial extent of subclinical atherosclerosis detected by vascular ultrasound and noncontrast cardiac CT, reported Valentin Fuster, MD, PhD, of the Icahn School of Medicine at Mount Sinai in New York City and Centro Nacional de Investigaciones Cardiovasculares Carlos III in Madrid, and colleagues.
This association was independent of traditional cardiovascular risk factors and was significant in all prediabetes groups, even below the prediabetes cutoff (HbA1c 5.5%-5.6%; OR 1.36, 95% CI 1.03-1.80,
Jun 1, 2021
SYNTAX: PCI, CABG confer similar long-term outcomes for elderly CAD patients
Whether elderly patients with 3-vessel disease (3VD) and/or left main coronary artery disease (LMCAD) underwent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) for revascularization, their ten-year rates of all-cause mortality, life expectancy, five-year major adverse cardiac or cerebrovascular events (MACCE), and five-year quality of life (QOL) were comparable, according to results of the SYNTAX Extended Survival study.
Therefore, PCI “might be a reasonable alternative to CABG for elderly patients with 3VD and/or LMCAD,” concluded Masafumi Ono, MD, of University of Amsterdam, Amsterdam, the Netherlands, and fellow SYNTAX Extended Survival investigators.
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