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Patients with untreated advanced gastric or gastroesophageal junction (GEJ) cancer lived longer without disease progression with the addition of a fibroblast growth factor receptor (FGFR) inhibitor to chemotherapy, a randomized trial showed.
Median progression-free survival (PFS) increased from 7.4 months with chemotherapy alone to 9.5 months with bemarituzumab. The size of the PFS benefit increased with levels of FGFR2b expression. Median overall survival (OS) was 12.9 months with chemotherapy and not yet reached in patients who also received the FGFR2b inhibitor.
Adverse events (AEs) that occurred more often with bemarituzumab included stomatitis and ocular effects, particularly corneal AEs, reported Zev Wainberg, MD, of the University of California Los Angeles, at the Gastrointestinal Cancer Symposium virtual meeting.