NIH creates database to track neurological effects of COVID-19
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WESTON, Fla. – The National Institutes of Health is now launching a database to track neurological symptoms associated with COVID-19 with the hopes of gaining greater understanding about the impact of the virus on the brain, spinal cord, nerves and muscles.
“I think this is a wonderful idea and is very important because we see patients all the time who have COVID, some of them go through the disease process easily and some of them end up in the intensive care unit. A lot of them wind up with symptoms from delirium to stroke, which is what I treat, to other symptoms that are more subtle like depression, anxiety and fatigue. We see these patients, but we can’t put it all together because we don’t have a large sample,” said Dr. Michal Obrzut, a neurologist with the Cleveland Clinic Weston.
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Mothers with COVID-19 produced a robust antibody response, but transfer of antibodies across the placenta to their infants was less efficient than expected, researchers found.
In an analysis of pregnant women who had COVID-19, neutralizing activity which measures the potency of antibody response was detected in 94% of maternal blood samples and only 25% of cord blood, according to Naima Joseph, MD, MPH, of Emory University in Atlanta, and colleagues.
The overall cord-to-maternal anti-receptor binding (RBD) immunoglobulin (Ig)G ratio was 81%, Joseph reported at the Society for Maternal-Fetal Medicine annual meeting. There is a maternal antibody response that is robust following infection, Joseph said in her presentation. But while she emphasized that anti-RBD domain IgG titers were detected in umbilical cord samples, she said it was unexpected that the efficiency of transfer was less than 1.