Integrative Approaches to Identifying Function and Significance of Adiposity Susceptibility Genes
In 2019, ~100 million Americans were obese, fueling increases in obesity-related morbidity, mortality, and health care costs, largely from cardiometabolic diseases (CMD). GWAS have demonstrated the fundamental role of genetic susceptibility in obesity risk, including the >1000 loci identified to date. Each GWAS-identified locus potentially provides novel biologic insight; yet the identification of the functional variants, genes, and underlying pathways at these loci has limited translation for precision medicine. OMICs (e.g. genetics, transcriptOMICs, methylOMICs, and metabolOMICs) lie along pathways linking genetic susceptibility to obesity and are emerging as powerful disease biomarkers that provide targetable “mechanistic bridges” linking GWAS findings with obesity risk. OMIC scans in the same individuals in which obesity associated loci discoveries were made are now available,
While the amount of antibodies transferred was less than expected, Emory researchers call the evidence reassuring. Author: Liza Lucas Updated: 7:29 AM EST February 2, 2021
ATLANTA A new study may provide some much-needed reassurance for women who are pregnant during the pandemic.
The study, conducted by researchers at Emory University School of Medicine, found evidence that COVID-19 antibodies can indeed transfer from mom to baby. It s scary to be pregnant during the coronavirus pandemic, Dr. Martina Badell, an associate professor in the Department of Gynecology & Obstetrics, told 11Alive. We started a protocol at Emory after the virus hit to study the immune response to COVID-19 infection in pregnancy.
E-Mail
IMAGE: Kendall Nettles, Ph.D., a molecular biologist at Scripps Research, Florida, collaborated with experts in many disciplines to systematically improve the safety of glucocorticoids. view more
Credit: Scripps Research
JUPITER, FL - A collaboration led by Scripps Research has developed a way to separate the beneficial anti-inflammatory properties of a group of steroids called glucocorticoids from some of their unwanted side-effects, through an optimization process they named ligand class analysis.
Their process enabled them to engineer two new, drug-like compounds that show steroidal anti-inflammatory action and other specific traits. One boosts muscle and energy supply, while the other reduces risk of muscle-wasting and bone loss typical of such drugs.
Pain relief medications like Tylenol and Advil are perfectly fine – but only after COVID-19 vaccine, experts say Adrianna Rodriguez, USA TODAY
Replay Video UP NEXT
Avoid pain relief medications just before getting the COVID-19 vaccine, but they are perfectly fine to take after, experts say.
Headache, fever, body aches and chills.
While these are completely normal side effects of the COVID-19 vaccine – and a good sign your immune system is working – they can be unpleasant.
To minimize the discomfort, some Americans may turn to pain relievers such as acetaminophen or ibuprofen. Others worry these medications could blunt the effectiveness of the vaccine.
The World Health Organization walked back a recommendation it made earlier this week saying pregnant woman should not get the Moderna coronavirus vaccine, instead saying women who are pregnant should be offered a vaccine upon consulting with a medical professional.