Researchers have discovered a long noncoding RNA whose function was previously unknown that turns out to play an important role in promoting the body s immune response against cancer and holds promise for enhancing the efficacy of anti-cancer immunotherapy.
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IMAGE: An X-ray crystallography image showing an ASH1L inhibitor developed at U-M in complex with the protein. view more
Credit: Grembecka / Cierpicki Labs
The protein made by the ASH1L gene plays a key role in the development of acute leukemia, along with other diseases. The ASH1L protein, however, has been challenging to target therapeutically.
Now a team of researchers led by Jolanta Grembecka, Ph.D., and Tomasz Cierpicki, Ph.D., from the University of Michigan has developed first-in-class small molecules to inhibit ASH1L s SET domain preventing critical molecular interactions in the development and progression of leukemia.
EXPERTS ADVISORY
The FDA has announced that it will ban menthol cigarettes and flavored cigars within the next year, a move the tobacco industry has pushed against for the last decade. University of Michigan experts can comment.
David Mendez
Thuy Le of the Department of Health Management and Policy at the School of Public Health recently authored a study showing that menthol cigarettes contributed to 378,000 premature deaths in the United States between 1980 and 2018.
“Successful implementation of the FDA’s proposed ban on menthol cigarettes has the potential to save hundreds of thousands of lives over a short period and reduce health inequalities, particularly for African Americans,” Mendez said. “While menthol cigarettes were responsible for around 380,000 premature deaths in the U.S. over the last four decades, a disproportionately large number of those deaths occurred among the African American population.”
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