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DNA methylation changes and characteristics in neurons of bipolar disorder patients

IMAGE: (Left) The number of hypermethylated DNA regions in both neuronal and non-neuronal cells is reduced in the bipolar patient group (BD) compared to the healthy group (CT). Credit: Professor Kazuya Iwamoto A research collaboration based in Kumamoto University, Japan has revealed the DNA methylation status of gene transcriptional regulatory regions in the frontal lobes of patients with bipolar disorder (BD). The regions with altered DNA methylation status were significantly enriched in genomic regions which were reported to be genetically related to BD. These findings are expected to advance the understanding of the pathogenesis of BD and the development of therapeutic drugs targeting epigenetic conditions.

Kazuya iwamotoKumamoto universityProfessor kazuya iwamotoMolecular psychiatryMedicine healthPharmaceutical scienceMental healthகுமாமோடோ பல்கலைக்கழகம்மூலக்கூறு மனநல மருத்துவம்உயிர் வேதியியல்

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How do bad kidneys lead to heart disease? Broken cellular clocks provide new clues

Kyushu University researchers find that one of the causes of CKD induced heart failures is the over expression of G protein-coupled receptor 68 in monocytes. Monocyte disruption was caused by the activation of the Clock gene, the key regulator of circadian rhythm via the increased level of vitamin A in the body resulting from kidney dysfunction.

Yuya yoshidaNaoya matsunagaShigehiro ohdoKengo hamamuraHiroyuki tsutsuiAkito tsurutaHitoshi kuroseHideaki kondoTomomi ideMichio nakayaTakaharu nakaoMasayuki kurogiSatoru koyanagiNature communicationsKyushu universityKyushu university faculty of pharmaceutical sciences

New study further advances the treatment of chronic pain

Scientists from the Immuno-Pharmacology and Interactomics group at the Luxembourg Institute of Health (LIH), in collaboration with the Center for Drug Discovery at RTI International (RTI), have demonstrated that conolidine, a natural painkiller derived from the pinwheel flower and traditionally used in Chinese medicine, interacts with the newly identified opioid receptor ACKR3/CXCR7 that regulates opioid peptides naturally produced in the brain. The researchers also developed a synthetic analogue of conolidine, RTI-5152-12, which displays an even greater activity on the receptor.

Andy chevignOjas namjoshiMartyna szpakowskaMarkus ollertMinistry of higher educationDepartment of infectionNature communicationsImmunity of the luxembourg institute healthEuropean commissionLuxembourg national research fundLuxembourg instituteDrug discoverySignal transductionTargeted therapyProf markus ollertHigher education

A sticky subject: Studying shellfish for advanced adhesives

E-Mail IMAGE: Wilker notes that not everyone in his lab has a chemistry degree; some of the lab members are shellfish about 1,000 of them to be exact. The shellfish play. view more Credit: Purdue University photo/Rebecca McElhoe Don t look now, but you re surrounded. Really. Within arm s reach - probably even touching you - are troublesome, sticky, potentially even toxic, substances. Bad for the planet, permanent, maybe even bad for your health. They re in your shoes, in your phone, in your laptop, lurking in the folds of envelopes, on books, in the chair you re sitting in, the flooring beneath your feet, and in uncountable other objects in your house, office and everyday world.

Jonathan wilkerMussel polymers incPurdue universityTrademark officeOffice of naval researchPurdue research foundation office of technology commercializationCollege of scienceNational science foundationNaval researchPurdue research foundation officeTechnology commercializationMussel polymersEcology environmentMarine freshwater biologyChemistry physics materials sciencesBiomechanics biophysics