Broad Institute of MIT and Harvard
Sickle cell disease (SCD) is the most common deadly genetic disorder, affecting more than 300,000 newborns worldwide each year. It leads to chronic pain, organ failure, and early death in patients. A team led by researchers at the Broad Institute of MIT and Harvard and St. Jude Children’s Research Hospital has now demonstrated a base editing approach that efficiently corrects the mutation underlying SCD in patient blood stem cells and in mice. This gene editing treatment rescued the disease symptoms in animal models, enabling the long-lasting production of healthy blood cells.
The root of SCD is two mutated copies of the hemoglobin gene, HBB, which cause red blood cells to transform from a circular disc into a sickle shape setting off a chain of events leading to organ damage, recurrent pain, and early mortality. In this study, the researchers used a molecular technology called base editing to directly convert a single letter of pathogenic DNA
Islamabad : The National University of Sciences & Technology , the Institute of Electrical and Electronics Engineers and Huawei organised the Annual International Conference on Digital Futures and.
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The Export Import Bank of the United States (EXIM) issued its 2020 annual report highlighting EXIM s
results and priority initiatives in its mission to support American
jobs by facilitating the export of U.S. goods and services. EXIM,
an independent federal governmental agency, is authorized by
Congress until 2026 to maintain $135 billion of credit exposure.
Through direct loans, guarantees, credit insurance, and supply
chain financing support, EXIM finances U.S. exporters and suppliers
that cannot arrange export financing from private sources without
EXIM s credit support. EXIM also provides foreign buyers of
The Export Import Bank of the United States EXIM issued its 2020 annual report highlighting EXIM’s results and priority initiatives in its mission to support American jobs by facilitating the export of U.S. goods and services.
The Export Import Bank of the United States (EXIM) issued its 2020 annual report highlighting EXIM’s results and priority initiatives in its mission to support American jobs by.