Wim Hof, the Iceman
Wim Hof, the Iceman, is extraordinarily resistant to extreme cold. His Wim Hof Method (WHM) combines breathing exercises, cold exposure, and meditation. Hyperventilation has been shown to reduce the body’s response to inflammation, but Hof’s extravagant claims of health benefits are not supported by scientific evidence.
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Wim Hof, also known as “The Iceman”, is a 61-year-old Dutch extreme athlete famous for his ability to withstand extreme cold. He has set several Guinness World Records for swimming under ice, for prolonged full-body contact with ice, and for a barefoot half-marathon on ice and snow.
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SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development
As efforts to find effective antivirals to combat the SARS-CoV-2-caused COVID-19 pandemic continue, a new study explores the viral enzyme PLpro, encoded in the nonstructural protein nsp3, and its inhibitors. The study appeared as a preprint on the
bioRxiv server in December 2020.
The Nsp3 Protein
The viral genome encodes 16 non-structural proteins, of which nsp3 is the largest. This is a membrane protein with multiple domains and is essential within the replication-transcription complex formed on the host membranes. It is also a protease, encoding the papain-like protease PLpro that is required for the release of several other non-structural proteins from the polypeptide.