Columbia University Irving Medical Center
Silver nanoclusters-which could be applied to the treatment of cancer in the future-block an early step of DNA replication, a new study by researchers in the Institute for Cancer Genetics at Columbia University Vagelos College of Physicians and Surgeons and the Herbert Irving Comprehensive Cancer Center has found.
Silver nanoclusters, which contain just a few to tens of atoms, are a more recent addition to the collection of silver nanomaterials, including larger-sized silver nanoparticles.
“In the long term, we may be able to harness the toxicity of silver nanoclusters.”
Because of silver nanoclusters’ unique chemical characteristics, they are used in a wide array of applications, including antimicrobial agents and electronics, and are being investigated for use in cancer imaging and drug delivery.
The only way to end the COVID-19 pandemic is to immunize enough people worldwide. The slogan “no one is safe until we are all safe” captures the epidemiological reality we face. Outbreaks anywhere could spawn a SARS-CoV-2 variant that is resistant to vaccines, forcing us all back into some form of lockdown. Given the emergence of worrisome new mutations in India, Brazil, South Africa, the United Kingdom, and elsewhere, this is no mere theoretical threat.
Worse, vaccine production is currently nowhere close to delivering the 10-15 billion doses needed to stop the spread of the virus. By the end of April, only 1.2 billion doses had been produced worldwide. At this rate, hundreds of millions of people in developing countries will remain unimmunized at least until 2023.
U.S. Ambassador To Liberia, McCarthy Visits NPHIL Complex and Liberia Chimp Rescue and Protection U.S. Ambassador To Liberia, McCarthy Visits NPHIL Complex and Liberia Chimp Rescue and Protection
The United States Ambassador Michael McCarthy to Liberia, and Deputy Chief of Mission Alyson Grunder visited the National Public Health Institute of Liberia (NPHIL) complex in Margibi County, formerly known as Liberia Institute for Biomedical Research (LIBR).
The National Reference Laboratory (NRL) currently shares diagnostic and office space in the complex. In addition, Liberia Chimpanzee Rescue and Protection, a non-governmental organization dedicated to bringing abandoned baby and juvenile chimps back to health, has facilities nearby.
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IMAGE: Model of NusA-dependent and NusG-dependent intrinsic termination of transcription of DNA into RNA. A new study shows that NusA and NusG together facilitate termination at about 88% of the intrinsic. view more
Credit: Babitzke Laboratory and Dani Zemba, Penn State
The protein, known as NusG, pauses the transcription machinery at specific DNA sequences to facilitate what is called intrinsic termination and prevent unwanted transcription that could disrupt cellular function.
A new study, led by Penn State researchers, shows that NusG and the related protein, NusA, together facilitate termination at about 88% of the intrinsic terminators in the bacteria Bacillus subtilis. Understanding this process expands our basic knowledge of this key cellular function and could eventually aid in the development of antibiotics that target and disrupt gene regulation in bacteria. A paper describing the research appears online in the journal