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Ludwig Cancer Research study reveals how circular ecDNA is generated and drives drug resistance in cancer
Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to generate drug resistance in cancer. The research, published on December 23 in the journal Nature, provides new insights into how cancers evolve to adapt to changing environments and suggests ways to reduce drug resistance by combining therapies.
“Drug resistance is the most problematic part of cancer therapy,” said Ofer Shoshani, a postdoctoral researcher in Cleveland’s lab and the study’s first author. “If not for drug resistance, many cancer patients would survive.”
3,401 COVID-19 deaths in 1 day likely fueled by Thanksgiving gatherings, travel
Hundreds of people in need wait in line to receive toys and food at the Grace Food Pantry s Christmas event in Everett, Massachusetts on December 19, 2020. - The pantry has been running seven days a week since the pandemic started and provided thousands of families with the food they need to survive. (Photo by Joseph Prezioso / AFP) (Photo by JOSEPH PREZIOSO/AFP via Getty Images)
by: Holly Yan and Eric Levenson, CNN
Posted:
Dec 23, 2020 / 03:43 PM EST
(CNN) Thousands more families just lost a loved one this holiday season as the U.S. reported its second-highest number of coronavirus deaths in one day 3,401 on Tuesday, according to Johns Hopkins University.
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23/12/2020 09:02 GMT+7
Nice weather anticipated over Christmas, New Year
All three regions of Vietnam are forecast to enjoy nice weather, perfect for entertainment activities during Christmas, while spells of rain and sunshine are expected in the south, with extreme cold set to hit the north over the New Year.
According to the National Centre for Hydro-meteorological Forecasting, temperatures between Dec. 23 and Dec. 25 in the northern region are expected to fluctuate between 13 and 16 degrees Celsius.
Most notably, the lowest temperatures are predicted to hit northern mountainous regions, ranging between 7 and 12. The highest temperatures in northern localities such as Lai Chau, Dien Bien, and Son La will hover around between 18 and 25.
Гороскоп на 23 декабря 2020 года для всех знаков Зодиака: день успешных начинаний - Астрология tsn.ua - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tsn.ua Daily Mail and Mail on Sunday newspapers.