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Scientists solve 100-year-old cerebral malaria mystery using neuroimaging techniques

 E-Mail Scientists have shown for the first time that cerebral malaria causes death in adults by triggering oxygen-deprivation in the brain, in new research published in Clinical Infectious Diseases. Already available treatments, such as hypothermia, may slow brain oxygen-deprivation in cerebral malaria patients. The researchers say these neuronal survival-enhancing approaches could soon be trialled in adults with cerebral malaria, alongside existing anti-malarial treatments, to hopefully improve survival. In 2019, there were an estimated 229 million cases of malaria worldwide. The estimated number of malaria deaths stood at 409,000 in 2019. Cerebral malaria is a severe, life-threatening complication of Plasmodium falciparum infection, the most widespread and lethal of the five malaria parasites that can infect humans through the bite of Anopheles mosquitoes. Up to 20% of people with cerebral malaria die despite anti-malarial treatment, and neurocognitive after-effects are comm

Medigen applies to begin phase 2 trials of its COVID-19 vaccine

CNA file photo Taipei, Dec. 16 (CNA) Taiwan s Medigen Vaccine Biologics Corp. (MVC) has applied to begin phase 2 testing of its COVID-19 vaccine, becoming the third local developer seeking permission to test the efficacy of its product on a larger scale, the company said Tuesday. In a statement, Medigen said all participants in its phase 1 trial had completed the two-dose regimen of the vaccine, allowing researchers to obtain data on its safety and ability to elicit an immune response. The company said it had applied with Taiwan s Food and Drug Administration (FDA) for permission to begin phase 2 clinical trials to test the vaccine s efficacy on 3,700 volunteers.

Nearly one-quarter of the world s population may not have access to coronavirus vaccines until 2022

Researchers looked  at all pre-orders for coronavirus vaccines that had been publicly announced by November 15 At least 7.48 billion doses - enough to inoculate 3.76 billion people - from 13 manufacturers such as AstraZeneca, Pfizer, Moderna and Johnson & Johnson A total of 51% will go to high-income countries such as the U.S., Canada, the U.K., Australia and Japan, despite accounting for 14% of the global population If all candidates were scaled up, there would be 5.96 billion courses by the end of 2021, leaving one-fourth of the global population without vaccines until 2022

6 more Northwest deaths from COVID-19

6 more Northwest deaths from COVID-19
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