55 which revealed that males have a higher risk of hyperuricemia. The higher likelihood of hyperuricemia in males than females may be due to the action of sex hormones, in that the female sex hormone estrogen helps in the excretion of uric acid and could have the ability to maintain blood uric acid levels.
56,57 Besides, the risk of exposure to environmental and dietary factors that aid the synthesis of purine is higher in males than females, which may also contribute to the production of more uric acid owing to regulatory activity of purine metabolism, which further results in the release of high levels of uric acid into the circulation.
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