New CAR T Approach Clears Brain Cancer Tumors in Preclinical Models
Fluorescence labelling of distinct layers of the brain. Each color represents a different cell type within the cortex. [Maria Bergamasco, Walter and Eliza Institute of Medical Research]
May 10, 2021
Fluorescence labelling of distinct layers of the brain. Each color represents a different cell type within the cortex. [Maria Bergamasco, Walter and Eliza Institute of Medical Research]
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Scientists in Australia report that they used chimeric antigen receptor (CAR) T cell therapy to clear brain cancer tumors in preclinical models. The team, which published its study (“Novel high‐affinity EGFRvIII‐specific chimeric antigen receptor T cells effectively eliminate human glioblastoma”) in
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IMAGE: New SaferSeqS technology detects rare mutations in blood in a highly efficient manner and reduces the error rate. view more
Credit: Elizabeth Cooke
Next-generation gene sequencing (NGS) technologies in which millions of DNA molecules are simultaneously but individually analyzed theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream. Identifying such mutations enables earlier diagnosis of cancer and can inform treatment decisions. Johns Hopkins Kimmel Cancer Center researchers developed a new technology to overcome the inefficiencies and high error rates common among next-generation sequencing techniques that have previously limited their clinical application.
To correct for these sequencing errors, the research team from the Ludwig Center and Lustgarten Laboratory at the Johns Hopkins Kimmel Cancer Center developed SaferSeqS (Safer Sequencing System), a major improvement to widely used tec
Lauren Roberts (ABC)
1 May, 2021, 3:20 pm
Studies have shown vaccines
prompt a T-cell response,
these responses have varied
from person to person and it
hasn’t been clear why.
Picture: AP/RAJANISH KAKADE
Right now, white blood cells known as T-cells are cruising through your body looking for any signs of an infection.
New research has shown your genetics influence how well these immune system cells respond to SARS-CoV-2 (the virus that causes COVID-19).
But can your genetic make-up also influence how your T-cells react to the COVID-19 vaccine?
That’s the question Australian scientists like Corey Smith are keen to answer.
A team of Australian researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI), the Doherty Institute, and the Kirby Institute have identified neutralizing nanobody cocktails that block the SARS-CoV-2 virus from entering cells in pre-clinical models.
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