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IMAGE: Sarah K. Wood, M.D., senior author, interim dean and senior associate dean for education, Schmidt College of Medicine. view more
Credit: Florida Atlantic University
Deaths from suicide are rising in the United States. These rising trends are especially alarming because global trends in suicide are on a downward trajectory. Moreover, in the U.S., the major mode of suicide among young Americans is by firearms.
Researchers from Florida Atlantic University s Schmidt College of Medicine and collaborators explored trends in suicide by firearms in young white and black Americans (ages 5 to 24 years) from 1999 to 2018. Results, published in the journal
The Microbiome Gains Momentum in Cancer Immunotherapy The Microbiome Gains Momentum in Cancer Immunotherapy
Vedanta Biosciences develops drugs made from defined bacterial consortia. One of these drugs, a cancer drug called VE800, addresses a challenge that may commonly occur with microbiome-engaging cancer immunotherapeutics. The problem is variability in microbiome signatures. Vedanta’s CEO, Bernat Olle, PhD, says that with cancer, there is no “night and day type of signature” like that seen with Clostridium difficile infections. Olle suggests that overcoming this problem will require big data sets, big sample sizes, and multiomic analyses.
The Microbiome Gains Momentum in Cancer Immunotherapy
Study: H2AK119ub1 is necessary for maternal inheritance of H3K27me3
An epigenetic study at the RIKEN Center for Integrative Medical Sciences shows that in mouse egg cells, modifications to histone H2A at lysine 119 lay the groundwork for inherited DNA functional modifications from the mother.
In books and the movies, a group of people on a special mission always sends out a scout to do reconnaissance before they proceed. Sometimes, the scouts leave signs or markers that allow the group to know where there should go.
Researchers led by Azusa Inoue at the RIKEN Center for Integrative Medical Sciences in Japan have discovered a mark left behind in unfertilized egg cells that determine which DNA modifications will be inherited if the egg is fertilized.
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Inheriting acquired traits requires trailblazer modifications to unfertilized eggs
An epigenetic study at the RIKEN Center for Integrative Medical Sciences shows that in mouse egg cells, modifications to histone H2A at lysine 119 lay the groundwork for inherited DNA functional modifications from the mother.
In books and the movies, a group of people on a special mission always sends out a scout to do reconnaissance before they proceed. Sometimes, the scouts leave signs or markers that allow the group to know where there should go. Researchers led by Azusa Inoue at the RIKEN Center for Integrative Medical Sciences in Japan have discovered a mark left behind in unfertilized egg cells that determine which DNA modifications will be inherited if the egg is fertilized. Specifically, they found that without initial modifications to histone H2A at lysine 119-technically called H2AK119ub1-later inheritable modifications would not occur. When allowed to develop, one consequence of