Heat stress while pregnant can predispose piglets to health complications, diminished performance later.
May 18, 2021
Piglets born to heat-stressed sows may carry the burden of their mom’s discomfort later in life in the form of health complications and diminished performance. Now, this so-called “in utero heat stress” may also hypersensitize the piglet’s immune system, potentially doing more harm than good to the young animals, a team of Agricultural Research Service (ARS) and university scientists has learned.
Pigs are more susceptible to heat stress due to an inability to sweat. This places them at greater risk of health and production problems that can add up to millions of dollars annually in revenue losses to swine producers.
ASF vaccine production no longer has to rely on live pigs and their fresh cells.
The U.S. Department of Agriculture’s Agricultural Research Service (ARS) announced May 7 that an African swine fever (ASF) vaccine candidate has been adapted to grow in a cell line, which means that those involved in vaccine production will no longer have to rely on live pigs and their fresh cells for vaccine production.
“This opens the door for large-scale vaccine production, which is a valuable tool for the possible eradication of the virus,” said senior ARS scientist Dr. Manuel Borca.
ASF is known to cause virulent, deadly outbreaks in wild and domestic swine, causing widespread and lethal outbreaks in various countries in Eastern Europe and throughout Asia. While ASF is not a threat to humans and cannot be transmitted from pigs to humans, outbreaks have led to significant economic losses and pork shortages on local and global scales.
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New research led by Nita A. Limdi at the University of Alabama at Birmingham reports that the presence of chronic kidney disease is a major factor affecting the efficacy and safety of anticoagulant medications taken to prevent blood clots. The findings, reported in Clinical Pharmacology and Therapeutics, shine a spotlight on the effects of chronic kidney disease on the outcomes of patients taking traditional anticoagulants or newer direct-acting oral anticoagulants.
Patients with cardiovascular disease are frequently prescribed anticoagulants to prevent blood clots from forming and potentially leading to stroke or systemic embolism. The new study looked at traditional anticoagulants such as warfarin, and a newer class of direct-acting anticoagulants, such as apixaban, dabigatran and others.
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