Myelin‐specific T cells implicated in central nervous system disease in monkeys
Scientists have uncovered new clues implicating a type of herpes virus as the cause of a central nervous system disease in monkeys that s similar to multiple sclerosis in people.
The findings, published in the
Annals of Clinical and Translational Neurology, expand on previous work to understand the cause of the disease and potentially develop antiviral therapies. The work was led by scientists at Oregon Health & Science University. This gives us a better understanding of the model, said Scott Wong, Ph.D., senior author of the study and a scientist at the OHSU Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center. It draws more parallels to MS in people.
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Gene therapy for mitochondrial disease shows promise in animals
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Results from a long-term study of a gene therapy technique to prevent inherited mitochondrial disease show promise, researchers say.
Studies of the technique at Oregon Health & Science University in Portland show no adverse health effects in rhesus macaque monkeys and their offspring. The researchers said the technique could break the cycle of disease passed from mother to baby through mutations in mitochondrial DNA, or mtDNA.
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Though results of animal studies sometimes differ in humans, the findings bolster the scientific basis for mitochondrial replacement therapy, or MRT, in human clinical trials, the study authors said.
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