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Credit: The Wistar Institute PHILADELPHIA (April 1, 2021 Scientists at The Wistar Institute identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding microenvironment. The study, published in Nature Cell Biology, reports that methyltransferase-like 3 (METTL3) and 14 (METTL14) proteins moonlight as transcriptional regulators that allow for establishment of the senescence-associated secretory phenotype (SASP). Cellular senescence is a stable state of growth arrest in which cells stop dividing but remain viable and produce an array of inflammatory and growth-promoting molecules collectively defined as SASP. These molecules account for the complex crosstalk between senescent cells and neighboring cells and the effect of cellular senescence in various physiological processes and diseases. Although senescence is regarded as a potent barrier for tum

United statesAndrewv kossenkovRugang zhangTimothy nacarelliXue haoJianhuang linPingyu liuChristopherm davisTakeshi fukumotoM celeste simonUs department of defenseNational cancer instituteNational institutes of healthZhang labCancer centerUniversity of pennsylvania