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PE registra maior número de óbitos desde agosto e o segundo maior número de casos por Covid-19 da pandemia
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Pulse Oximeter Market Size Worth $3 4 Billion By 2028 | CAGR: 6 4%: Grand View Research, Inc
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Study maps crucial component of long-term immune response to SARS-CoV-2
Researchers in the United States have found that protective antibodies generated against the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)– the agent that causes coronavirus disease 2019 (COVID-19) – also protect against viral variants.
Monoclonal antibodies derived from memory B cell reserves in convalescent individuals competed to bind the spike protein of both the original SARS-CoV-2 strain and variant strains. The spike protein is the main surface structure the virus uses to bind to and infect host cells.
Duane Wesemann from Harvard Medical School in Boston and colleagues say the study maps a crucial component of the long-term immune response to SARS-CoV-2 infection.
Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines
Lipid nanoparticles (LNPs) are the carrier vehicles that protect messenger RNA (mRNA) molecules from degradation and aid intracellular delivery and endosomal escape in the nucleoside-modified mRNA-LNP vaccine platforms currently used by Pfizer/BioNTech and Moderna, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These two vaccines surpass the rest with their effective support for T follicular helper cells (Tfh) and the protective humoral responses observed in the preclinical trials.
While the vital role of LNPs in these vaccines action is established, the potentially inflammatory nature of these LNPs is not assessed. Also, in the Pfizer/BioNTech and Moderna vaccines human trials, it is reported that side effects often linked to inflammation, such as pain, swelling, fever, and sleepiness, are common.
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