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UltraViolet Devices, Inc. (UVDI) announced its V-MAX™ UV-C air disinfection technology has achieved 99.99% inactivation of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in a single-pass in moving airstream HVAC testing. The testing was conducted at Innovative Bioanalysis, a BEI-recognized BSL-3 laboratory in California. SARS-CoV-2 is the primary viral strain that causes the COVID-19 infection, which the Centers for Disease Control and Prevention (CDC) has indicated can be spread by both airborne and surface transmission.
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UVDI UV-C Indoor Air Quality technology is installed in over 10,000 commercial buildings globally, including office buildings, airports, healthcare facilities and schools. (Photo: Business Wire)
In the independent testing, UVDI V-MAX™ UV-C air disinfection technology eliminated
Researchers based in Beijing and Shenzhen, China, report that they have identified mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may allow variant strains to avoid neutralization by monoclonal antibodies and convalescent blood plasma.
Study addresses glycosylation concerns in SARS-CoV-2 vaccine design
An international team of researchers has found that glycosylation patterns are conserved across the native spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – and the recombinant spike proteins made in laboratories for use in vaccines.
The spike protein, which SARS-CoV-2 uses to bind to and infect cells, is the main target of neutralizing antibodies following natural infection with the virus or vaccination.
A central tenet in vaccine design is the presentation of native-like antigens that will induce protective immunity. The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity between the many different vaccine candidates under investigation, says Max Crispin from the University of Southampton in the UK and colleagues.
A new preprint research paper, posted to the bioRxiv server, uncovered more information on the different structural conformations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The findings suggest the spike protein turns into a locked state to stabilize the spike protein during virus egress.