Abstract
Introduction: Chronic kidney disease (CKD) is a risk factor for herpes zoster (HZ) infection. Few studies have examined HZ vaccine (HZV) in this population. We conducted a systematic review and meta-analysis investigating the efficacy and safety of HZV in patients with renal disease (CKD, dialysis, and transplant). Methods: MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases (up to May 2020) were searched for randomized controlled trials and nonrandomized controlled studies evaluating HZV in patients with CKD for effectiveness and adverse event risks. Studies without a control group (placebo or no vaccine) were excluded. Extraction of prespecified data and risk of bias assessments using the Newcastle-Ottawa scale for cohort studies and the Cochrane Risk of Bias Tool for randomized controlled trials were done by 3 authors. Random-effects meta-analysis was used to generate pooled treatment effects and 95% confidence intervals. Results: Incl
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Comparative effect of physical exercise versus statins on improving arterial stiffness in patients with high cardiometabolic risk: A network meta-analysis
Iván Cavero-Redondo,
Affiliation Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain
Affiliation Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom ⨯
Celia Alvarez-Bueno ,
Affiliation Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom
Affiliation Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain ⨯
Malcolm Price,
Affiliation Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom
Affiliation Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain
Ivermectin is effective for COVID-19: real-time meta analysis of 35 studies
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•100% of the 35 studies to date report positive effects. Early treatment is more successful, with an estimated reduction of 84% in the effect measured using a random effects meta-analysis, RR 0.16 [0.08-0.33]. Prophylactic use also shows high effectiveness.
•100% of the 17 Randomized Controlled Trials (RCTs) report positive effects, with an estimated reduction of 71%, RR 0.29 [0.17-0.51].
•The probability that an ineffective treatment generated results as positive as the 35 studies to date is estimated to be 1 in 34 billion (
p = 0.000000000029).
We analyze all significant studies concerning the use of ivermectin for COVID-19. Search methods, inclusion criteria, effect extraction criteria (more serious outcomes have priority), all individual study data, PRISMA answers, and statistical methods are detailed in Appendix 1. We present random effects meta-analysis results for all studies, f
Dr. Daniel Kopans.
The history of the U.S. Preventive Services Task Force (USPSTF) on breast screening is another case in point, in which decisions on mammography guidelines have been based on flawed analyses of scientific data.
When the USPSTF last week opened a new review of breast screening guidelines, it created the opportunity to revisit the group s flawed decision in 2009 to not recommend breast screening for women in their 40s. However, a number of factors need to be addressed for the 2021 review to present a fair and impartial review of the science and evidence in favor of breast screening.
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