In a study reported in the
Journal of Controlled Release, researchers from Okayama University describe the use of nanocarriers in selectively transporting anticancer drugs to brain tumors.
Glioblastoma is an aggressive form of brain cancer that is best treated with boron neutron capture therapy (BNCT). BNCT involves the use of an agent that delivers boron into tumor tissues. When subsequently hit with radiation, boron (typically the 10B isotope is used) emits particles that kill neighboring cells. However, current methods do not cargo boron into cancer cells homogenously. Now, Associate professor MICHIUE Hiroyuki and Okayama university Neutron Therapy Research Center (NTRC) team have successfully used a nanocarrier that selectively delivers boron into brain tumors.
Okayama University research: Nanotechnology for making cancer drugs more accessible to the brain
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Mª José Alonso ingresa como miembro en la Academia de Medicina de Bélgica
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Researchers develop ultra-small nanomedicines to target intractable cancers
Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.
Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation.
The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues.
Clinical trials and preclinical studies using the developed ultra-small nanomedicines are proceeding for cancer therapy.
Published in the website of
Journal of Controlled Release on January 6.
Main body
The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki-City in Japan, Abbreviation: iCONM) recently developed an ultra-small nanomedicines called Unit Polyion Complex (uPIC) in collaboratio