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 E-Mail The omega-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in oily fish. Researchers from the National Institute of Health Research (NIHR) Maudsley Biomedical Research Centre assessed the effects of high doses of EPA and DHA in lab-grown neurones and then in patients to help clarify how they reduce inflammation and depression. This novel approach allowed the scientists to identify an important molecular mechanism which can help inform the development of potential new treatments involving omega-3 fatty acids for patients with depression. Lead author Dr Alessandra Borsini, NIHR Maudsley BRC Senior Postdoctoral Neuroscientist at King s College London, said: Using a combination of laboratory and patient research our study has provided exciting new insight into how omega-3 fatty acids bring about anti-inflammatory effects that improve depression. For some time we have known that omega-3 PUFA can induce anti-depressant

United kingdomCity ofAlessandra borsiniSerena rianjongdeeAnna nicolaouFranca davenportCarmine parianteKing college londonNational institute of health researchSenior postdoctoral neuroscientist at king college londonAcademy of medical sciencesChina medical universityUniversity of manchesterNational institute for health researchHuman sciencesDepartment of health