His back injuries meant he was unable to pursue his career as a trauma surgeon.
In 1996 he joined the WHO and worked on Ebola and other major disease outbreaks. His work brought him to Uganda, Congo, Liberia, Sierra Leone and Afghanistan – often at great personal risk. He was also one of the key officials in the response to the Sars crisis over a decade ago.
His profile in developmental work was such that he was personally asked by Microsoft billionaire Bill Gates to assist with his third world vaccination programme.
Throughout the Covid-19 pandemic, Dr Ryan has championed agreed strategies to control the spread of the virus – and global co-operation with vaccination development.
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Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer s aggressiveness. The more unstable chromosomes are, the more likely that bits of DNA from these chromosomes will end up where they don t belong: outside of a cell s central nucleus and floating in the cytoplasm.
Cells interpret these rogue bits of DNA as evidence of viral invaders, which sets off their internal alarm bells and leads to inflammation. Immune cells travel to the site of the tumor and churn out defensive chemicals. A mystery has been why this immune reaction, triggered by the cancer cells, does not spell their downfall.