Researchers Pinpoint the Workings behind Liver Regeneration
Liver section images showing fluorescently label hepatocytes in distinct zones. Each row is a different strain of lineage tracing mouse. [UT Southwestern Medical Center]
February 26, 2021
Liver section images showing fluorescently label hepatocytes in distinct zones. Each row is a different strain of lineage tracing mouse. [UT Southwestern Medical Center]
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The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-to-bodyweight ratio is always at 100% of what is required for body homeostasis. When the liver is injured beyond its ability to regenerate itself, a liver transplant is needed and used to treat conditions such as liver cancer, cirrhotic liver disease, acute liver failure, and genetic liver disorders. The amazing regenerative power of the liver is no secret. However, the cells and mechanisms behind it remained a mystery, until now. Researchers from the Children’s Medica
Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced.
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IMAGE: Deep imaging of a mouse femur bone marrow showing that Osteolectin-expressing cells (red) are around arterioles (white) but not sinusoids (green). view more
Credit: UT Southwestern Medical Center
Scientists at the Children s Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study, published in
Nature, also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function.
Neighborhood Credit Union Donates a check of $25,000 to the Children’s Medical Center Foundation
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On Thursday, February 4, 2021, Neighborhood Credit Union donated a check of $25,000 to the Children’s Medical Center Foundation. Due to COVID-19 safety precautions, the presentation took place outside with a bird s eye view of the Children’s Medical Center Dallas.
From Left to Right: Jessie Swendig, VP of Marketing and Communications at Neighborhood Credit Union and Kendal Rowden, Development Officer, Corporate Partnerships at Children’s Medical Center.
“We are grateful to all of the members of Neighborhood Credit Union. Your donation will help make life better for children.”
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The Mark Foundation for Cancer Research (MFCR) has awarded seven grants to promising early-career investigators for projects aimed at addressing unmet needs in cancer research. The Emerging Leader Award program empowers scientists to take on innovative, high-risk/high-reward projects that have significant potential to improve outcomes for cancer patients.
The 2021 MFCR Emerging Leaders are pursuing important studies in areas of basic, translational, and clinical cancer research, including probing the function of cancer stem cells in brain cancer, discerning the unique molecular features of lung cancer in older patients, and identifying therapeutic combinations that will increase the effectiveness of immune checkpoint inhibitors across multiple types of cancer.