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Markey Names Rogers as Director of Kentucky Cancer Program – East

Mindy Rogers has been named director of the Kentucky Cancer Program - East, housed within the UK Markey Cancer Center. LEXINGTON, Ky. (Jan. 20, 2021) – The University of Kentucky Markey Cancer Center announces the appointment of Mindy Rogers as director of the Kentucky Cancer Program – East, which is housed within the Cancer Center. The Kentucky Cancer Program (KCP) - East is one of the programs under Markey’s Community Impact Office. The KCP-East director works under the guidance of Markey’s Associate Director for Population Science and Community Impact Pamela Hull, Ph.D. In this role, Rogers will manage a staff of KCP-East Regional cancer control specialists whose efforts cover nine area development districts in the eastern half of the state.

Markey Study Shows Kentucky Endometrial Cancer Patients Have Higher Rates of DACH1 Mutation

A new study by Markey researchers shows a higher-than-average rate of DACH1 mutations in Kentucky patients with endometrial cancer. LEXINGTON, Ky. (Jan. 12, 2020)  A new study by University of Kentucky Markey Cancer Center researchers shows that DACH1 mutations are prevalent in Kentucky patients with endometrial cancer, suggesting that DACH1 may be a candidate biomarker for future trials with immunotherapy. DACH1 is a transcriptional repressor and tumor suppressor gene that is frequently mutated in other cancers, including melanoma, bladder and prostate cancer. The loss of DACH1 expression is also associated with poor prognosis and reduced survival in women with uterine cancer. Published in PLOS One, the study sought to determine the frequency of DACH1 mutations in patients with endometrial cancer in Kentucky. Using the Oncology Research Information Exchange Network (ORIEN), a personalized medicine consortium that Markey joined in 2017, researchers examined clinical and genomic

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