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SNP-Chip: CRISPR-Based Transistor Detects Single Point Mutations SNP-Chip enables amplification-free, electronic, detection of point mutations in DNA from patients with Sickle-Cell Disease and ALS Long before the COVID-19 pandemic shined a spotlight on CRISPR-based diagnostics, Kiana Aran, PhD, was developing the CRISPR-Chip. It was, according to Aran, the first transistor that uses CRISPR to search the genome for potential mutations. In addition, the graphene field-effect transistor (gFET) did not require amplification or sequencing of the nucleic acid. Now, two years after its introduction, a group headed by Aran, co-founder and CSO at Cardea Bio, and assistant professor at the Keck Graduate Institute of Applied Life Sciences, is introducing an improved CRISPR-based gFET system, named SNP-Chip.

Keck graduate instituteUnited statesSan diegoEmmanuelle charpentierMichael heltzenCardea bioKary mullisKiana aranJennifer doudnaKeck graduate institute of applied life sciencesCarolina state universityApplied life sciencesNature biomedical engineeringRodolphe barrangouNorth carolina state universityகேக்க் பட்டதாரி நிறுவனம்