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Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points

Share SARS-CoV-2 is a coronavirus, so named because spike proteins on its surface give it the appearance of a crown (‘corona’). The spike proteins bind to ACE2, a protein receptor found on the surface of cells in our body. Both the spike protein and ACE2 are then cleaved, allowing genetic material from the virus to enter the host cell. The virus manipulates the host cell’s machinery to allow the virus to replicate and spread. As SARS-CoV-2 divides and replicates, errors in its genetic makeup cause it to mutate. Some mutations make the virus more transmissible or more infectious, some help it evade the immune response, potentially making vaccines less effective, while others have little effect.

Glasgow cityUnited kingdomBo mengRavi guptaLaboratory of molecular biologyPirbright instituteMelinda gates foundationCambridge biomedical research centreUniversity of cambridgeNational institute for health researchGlasgow centre for virus researchCambridge institute of therapeutic immunologyResearch councilDepartment of medicineCell reportsGlasgow centre

Key mutations in Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points

University of Cambridge One of the key mutations seen in the ‘Alpha variant’ of SARS-CoV-2 – the deletion of two amino acids, H69/V70 – enables the virus to overcome chinks in its armour as it evolves, say an international team of scientists. SARS-CoV-2 is a coronavirus, so named because spike proteins on its surface give it the appearance of a crown (‘corona’). The spike proteins bind to ACE2, a protein receptor found on the surface of cells in our body. Both the spike protein and ACE2 are then cleaved, allowing genetic material from the virus to enter the host cell. The virus manipulates the host cell’s machinery to allow the virus to replicate and spread.

Glasgow cityUnited kingdomBo mengRavi guptaUniversity of cambridgeLaboratory of molecular biologyGlasgow centre for virus researchPirbright instituteCambridge institute of therapeutic immunologyDepartment of medicineCell reportsGlasgow centreVirus researchMolecular biologyCambridge instituteTherapeutic immunology

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Glasgow cityUnited kingdomBo mengRavi guptaEmily hendersonLaboratory of molecular biologyPirbright instituteMelinda gates foundationCambridge biomedical research centreUniversity of cambridgeNational institute for health researchGlasgow centre for virus researchCambridge institute of therapeutic immunologyResearch councilDepartment of medicineCell reports

Key mutations in the Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points

Key mutations in the Alpha variant enable SARS-CoV-2 to overcome evolutionary weak points
techexplorist.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from techexplorist.com Daily Mail and Mail on Sunday newspapers.

Glasgow cityUnited kingdomRavi guptaUniversity of cambridgeLaboratory of molecular biologyGlasgow centre for virus researchPirbright instituteCambridge institute of therapeutic immunologyGlasgow centreVirus researchMolecular biologyVir biotechnologyCambridge instituteTherapeutic immunologyInfectious diseaseDalan bailey

India will soon have another wave so get one dose to as many people as you can: Top virologist

India will soon have another wave so get one dose to as many people as you can: Top virologist
indiatimes.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from indiatimes.com Daily Mail and Mail on Sunday newspapers.

United kingdomAstra zenecaRavindrak guptaIndulekha aravindUniversity of cambridgeVirus threats advisory groupCambridge institute of therapeutic immunologyCambridge instituteTherapeutic immunologyInfectious diseasesEmerging respiratory virus threats advisory groupஒன்றுபட்டது கிஂக்டம்அஸ்ட்ரா ஸெநெகஇண்துழெக அரவிந்த்பல்கலைக்கழகம் ஆஃப் கேம்பிரிட்ஜ்கேம்பிரிட்ஜ் நிறுவனம் ஆஃப் சிகிச்சை நோயெதிர்ப்பு